Poxet (Dapoxetine) vs Other Premature Ejaculation Treatments

Premature Ejaculation Treatment Selector

Quick Guide: This tool helps you compare different treatments for premature ejaculation based on your preferences for timing, side effects, and cost.

Preferred Timing:

Side Effect Tolerance:

Budget Consideration:

Treatment Type Preference:

Treatment Overview

Treatment	Administration	Onset	Duration	Side Effects	Cost (USD/month)
Poxet (Dapoxetine)	On-demand	30-60 min	4-6 hours	Nausea, headache, dizziness	$70-$120
Paroxetine	Daily oral	2-3 weeks	24 hours	Nausea, sexual dysfunction, weight gain	$30-$50
Sertraline	Daily oral	2-3 weeks	24 hours	Diarrhea, insomnia, sexual dysfunction	$35-$55
Clomipramine	Daily oral	2-3 weeks	24 hours	Dry mouth, constipation, drowsiness	$25-$45
Lidocaine-Prilocaine Spray	Topical	5-10 min	30-60 minutes	Temporary numbness, skin irritation	$15-$25
Behavioral Techniques	No medication	Immediate	Variable	None (may cause performance anxiety)	$0

Quick Take

Poxet (dapoxetine) is a short‑acting SSRI specifically approved for premature ejaculation (PE).
Alternative oral SSRIs (paroxetine, sertraline, clomipramine) work but need daily dosing.
Topical anesthetics (lidocaine‑prilocaine spray) act locally and avoid systemic side‑effects.
Behavioral techniques (start‑stop, squeeze) cost nothing but require practice.
Choosing the right option depends on timing, side‑effects, cost, and whether you prefer on‑demand or daily use.

When it comes to managing premature ejaculation, Dapoxetine often tops the list because it’s the only drug officially labeled for on‑demand use. But it’s not the only game in town. Below we break down how dapoxetine stacks up against the most common alternatives, so you can decide which route matches your lifestyle and health profile.

What Is Poxet (dapoxetine) and How Does It Work?

Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) engineered for rapid onset and short half‑life, typically 1-2hours. It boosts serotonin levels in the central nervous system just long enough to delay ejaculation without the lingering mood‑changing effects of traditional SSRIs. The drug is taken 1‑3hours before sexual activity, and its effect lasts about 4-6hours, matching most intimate encounters. Because it clears the body quickly, withdrawal symptoms are minimal compared with daily SSRIs.

Key attributes of dapoxetine:

Dosage: 30mg or 60mg tablets, on‑demand.
Approval: European Medicines Agency (EMA) and several Asian regulators; not FDA‑approved in the U.S. yet.
Common side‑effects: nausea, headache, dizziness, rarely insomnia.

Common Alternatives to Dapoxetine

Below are the main contenders you’ll encounter when researching PE treatments.

Paroxetine is a classic SSRI used off‑label for PE. It requires a daily dose of 20mg, and steady‑state levels build up over 2-3weeks.

Sertraline works similarly, with daily dosing of 50‑100mg. It’s often favored for men who also need anxiety relief.

Clomipramine is a tricyclic antidepressant that doubles as a PE therapy; doses range from 25‑50mg per day.

Lidocaine‑prilocaine spray (often sold under brand names like TEMPE) provides local desensitization. Apply 5-10minutes before sex; effect lasts 30‑60minutes.

Start‑stop technique is a behavioral method where stimulation stops before the point of inevitability, waits, then resumes. No medication required.

Squeeze technique involves applying pressure to the penis shaft just before climax to reduce arousal. Like the start‑stop, it’s free but may feel awkward.

Side‑Effect Profile Comparison

Key differences between dapoxetine and common PE alternatives
Attribute	Dapoxetine (Poxet)	Paroxetine (daily SSRI)	Sertraline (daily SSRI)	Clomipramine (daily TCA)	Lidocaine‑prilocaine spray	Behavioral technique
Administration	On‑demand, 1‑3h before	Daily oral	Daily oral	Daily oral	Topical, 5‑10min before	No medication
Onset of effect	30‑60min	2‑3weeks	2‑3weeks	2‑3weeks	5‑10min	Immediate (practice‑dependent)
Duration	4‑6h	24h (continuous)	24h (continuous)	24h (continuous)	30‑60min	Variable
Common side‑effects	Nausea, headache, dizziness	Nausea, sexual dysfunction, weight gain	Diarrhea, insomnia, sexual dysfunction	Dry mouth, constipation, drowsiness	Temporary numbness, skin irritation	None (may cause performance anxiety)
Cost (2025 USD per month)	$70‑$120	$30‑$50	$35‑$55	$25‑$45	$15‑$25	$0
Regulatory status (US)	Not FDA‑approved (off‑label)	Approved for depression, off‑label for PE	Approved for depression, off‑label for PE	Approved for OCD, off‑label for PE	FDA‑approved for topical anesthesia	None

Decision Criteria: Which Option Fits You?

When you line up the numbers, the choice boils down to three personal factors:

Timing needs - If spontaneity is key, on‑demand dapoxetine or spray wins. If you’re comfortable planning, a daily SSRI may be cheaper long‑term.
Tolerance for side‑effects - Systemic drugs can affect mood, appetite, or sleep. Topicals stay local; techniques have no pharmacologic risk.
Budget and access - In 2025, dapoxetine is still pricier and may need import. Generic paroxetine or sertraline are widely covered by insurance.

For many men, a hybrid approach works: a daily low‑dose SSRI to set a baseline, plus an on‑demand spray for extra control. Always discuss with a physician, especially if you’re on other meds (e.g., nitrates, antidepressants) that could interact.

Practical Tips and Common Pitfalls

Start low, go slow - If trying dapoxetine, begin with 30mg. Upsize only if tolerated.
Don’t combine multiple oral SSRIs - Overlap can cause serotonin syndrome.
Timing the spray - Apply 5‑10minutes before intimacy and wipe off excess to avoid partner numbness.
Practice makes perfect - Behavioral methods need at least a few weeks of consistent practice before noticeable improvement.
Watch for contraindications - Dapoxetine isn’t for men with severe heart disease or taking monoamine oxidase inhibitors.

Frequently Asked Questions

Is dapoxetine safe for men with hypertension?

In most studies, dapoxetine didn’t raise blood pressure significantly. However, if you’re on beta‑blockers or other cardiac meds, talk to your doctor first.

Can I use both dapoxetine and a topical spray together?

Yes, many clinicians recommend a low dose of dapoxetine plus a spray for extra buffering. Just keep the spray amount modest to avoid over‑numbing.

How long does it take for daily SSRIs to improve PE?

Typically 2‑4weeks of consistent dosing are needed for noticeable delay. Some men report improvement as early as 1week.

Are there any natural supplements that work as well as dapoxetine?

Herbal extracts like yohimbine or horny goat weed have modest anecdotal support, but robust clinical data are lacking. They’re not a reliable replacement for FDA‑ or EMA‑approved treatments.

What should I do if I experience severe nausea with dapoxetine?

Take the tablet with food, reduce the dose to 30mg, or switch to a daily low‑dose SSRI. If nausea persists, stop the medication and seek medical advice.

Bottom line: dapoxetine offers the convenience of on‑demand use and a pharmacologic profile tuned for PE, but it isn’t the only path. By weighing timing, side‑effect tolerance, and cost, you can pick the strategy that feels right for your body and your bedroom life.

Comments

Mira Adam

October 5, 2025

Dapoxetine is just pharmaceutical convenience wrapped in a marketing suit-people forget that serotonin isn't a faucet you turn on and off without consequences.
Sue Haskett

October 5, 2025

Let’s be real: if you’re relying on a spray or a pill to have sex, you’re already missing the point. The body knows what it needs-practice, presence, and patience. No chemical can replace the connection built through slow, intentional intimacy. And yes, the start-stop technique feels awkward at first-but so did your first kiss. Growth isn’t comfortable. It’s worth it.
Jauregui Goudy

October 6, 2025

Y’all are overcomplicating this. I was on 30mg dapoxetine for 3 months-zero nausea, zero drama. My wife said I was ‘like a new man.’ Then I switched to sertraline 25mg daily-same results, half the cost. And guess what? I didn’t need to plan sex around a pill. If you’re scared of side effects, start low, talk to your doctor, and don’t let fear dictate your pleasure. You deserve to feel confident-no shame in using science to help your body work better.
Miriam Lohrum

October 8, 2025

It’s fascinating how we’ve reduced human intimacy to a pharmacological optimization problem. We treat PE like a software bug to be patched, when perhaps it’s a signal-a reminder that modern life has disconnected us from our biology. The spray works? Fine. The pill works? Okay. But what if the real solution isn’t in the bottle, but in the breath before touch, in the silence between heartbeats, in the courage to be vulnerable without chemical armor?
Sam HardcastleJIV

October 9, 2025

While your clinical comparisons are methodologically sound, one must acknowledge the epistemological limitations inherent in pharmaceutical-centric paradigms. The very framing of ‘treatment’ presupposes a pathological model of male sexuality, thereby reinforcing normative constructs of performance. One might posit that behavioral modalities, though labor-intensive, afford a phenomenological reclamation of agency-whereas pharmacological intervention, however efficacious, externalizes control to the pharmacopoeia. One is left to wonder: are we healing, or merely masking?